DCLK1

Across TCGA cell cohorts, DCLK1 mutation is significantly associated with the RNA expression of many other genes, with 397 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DCLK1-associated genes across cancer lineages are JOSD1, HMGXB4, and GNPNAT1. Each is linked with DCLK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCLK1-to-partner and partner-to-DCLK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JOSD1 grouped by DCLK1-low versus DCLK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCLK1→partner) and Y-score (partner→DCLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	JOSD1 →	+0.549	+3.321	.001	.003	3	1
LARGE_INTESTINE	HMGXB4 →	+0.531	+3.850	.002	<.001	3	1
LARGE_INTESTINE	GNPNAT1 →	+0.635	+2.829	<.001	<.001	3	1
LARGE_INTESTINE	ADNP2 →	+0.624	+2.043	.004	.008	3	1
LARGE_INTESTINE	RBBP8 →	+0.601	+2.043	.003	.008	3	1
LARGE_INTESTINE	NISCH →	+0.701	+3.252	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 397 associations by consensus.

JOSD1 by DCLK1 expression — LARGE_INTESTINE

Explore this box plot interactively →