DCK

Across TCGA patient cohorts, DCK mutation is significantly associated with the RNA expression of many other genes, with 115 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCK-associated genes across cancer lineages are RNU6-663P, TRAJ11, and C4A-AS1. Each is linked with DCK in more than 1 cancer types. Because this analysis shows association rather than direction, both DCK-to-partner and partner-to-DCK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-663P grouped by DCK-low versus DCK-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCK→partner) and Y-score (partner→DCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-663P →	+0.394	+5.812	<.001	.003	3	2
UCEC	TRAJ11 →	+0.675	+3.076	<.001	<.001	3	2
ESCA	C4A-AS1 →	+0.018	+5.450	<.001	.004	3	2
UCEC	RNA5SP414 →	+0.779	+3.518	<.001	<.001	3	1
UCEC	RN7SL197P →	+0.150	+2.792	.007	.006	3	1
UCEC	MIR6871 →	+0.756	+2.348	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 115 associations by consensus.

RNU6-663P by DCK expression — CESC

Explore this box plot interactively →