Across TCGA pan-cancer cohorts, DCHS2 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DCHS2 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DCHS2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DCHS2 expression acts as an unfavorable survival marker.

LUAD, HNSC, and UCEC are the cancer types where DCHS2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.486	0.844	.024	10	view →
HNSC	OS	Median	III,IV	0.896	1.000	.026	3	view →
UCEC	DFS	Median	All	0.710	1.000	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: DCHS2 tumor-vs-normal RNA expression · all DCHS2 data types