Across TCGA patient cohorts, DCHS2 mutation is significantly associated with the RNA expression of many other genes, with 10,213 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCHS2-associated genes across cancer lineages are POC1A, ZNF662, and ZNF511. Each is linked with DCHS2 in more than 6 cancer types. Because this analysis shows association rather than direction, both DCHS2-to-partner and partner-to-DCHS2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCHS2→partner) and Y-score (partner→DCHS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	POC1A →	+0.548	+4.034	<.001	<.001	3	7
SKCM	ZNF662 →	-0.707	-1.675	<.001	<.001	3	7
STAD	ZNF511 →	+0.376	+1.853	<.001	<.001	3	7
STAD	CDCA2 →	+0.825	+2.115	<.001	<.001	3	6
CESC	PFN4 →	-0.460	-2.970	.003	<.001	3	6
SKCM	PTN →	-0.904	-0.926	.005	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,213 associations by consensus.

Exploration

DCHS2 survival (RNA) · tumor vs normal (RNA) · all DCHS2 data types