Across TCGA cell cohorts, DCHS2 mutation is significantly associated with the RNA expression of many other genes, with 2,229 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DCHS2-associated genes across cancer lineages are NEDD1, CSNK1G1, and ZNF724. Each is linked with DCHS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DCHS2-to-partner and partner-to-DCHS2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCHS2→partner) and Y-score (partner→DCHS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NEDD1 →	+0.713	+3.228	.002	.004	3	4
BLOOD_Leukemia	CSNK1G1 →	+0.462	+3.730	.004	<.001	3	4
BLOOD_Leukemia	ZNF724 →	+0.835	+3.730	<.001	<.001	3	4
LARGE_INTESTINE	NDUFAF5 →	+0.444	+2.067	.003	.004	3	4
LARGE_INTESTINE	GTPBP3 →	+0.545	+1.628	.003	.002	3	4
LARGE_INTESTINE	PAQR3 →	+0.782	+1.969	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,229 associations by consensus.

Exploration

DCHS2 survival (RNA) · tumor vs normal (RNA) · all DCHS2 data types