Across TCGA pan-cancer cohorts, DCDC2B Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DCDC2B data layer compared with 26 for mass-spec protein and 2 for mass-spec protein.
The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher DCDC2B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DCDC2B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.
SKCM, STAD, and DLBC are the cancer types where DCDC2B Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.