DCDC2

Across TCGA patient cohorts, DCDC2 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCDC2-associated genes across cancer lineages are Src_pY527, EGFR_pY1068, and Smad3. Each is linked with DCDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCDC2-to-partner and partner-to-DCDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY527 grouped by DCDC2-low versus DCDC2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCDC2→partner) and Y-score (partner→DCDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Src_pY527 →	-0.557	-3.000	.002	.034	3	2
UCEC	EGFR_pY1068 →	-0.322	-2.502	.001	.002	3	2
UCEC	Smad3 →	+0.193	+3.807	.001	<.001	3	2
SKCM	NDRG1_pT346 →	-0.637	-2.115	.026	.018	3	1
SKCM	VEGFR2 →	+0.325	+2.321	.005	.033	3	1
UCEC	eEF2 →	+0.437	+2.000	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Src_pY527 by DCDC2 expression — SKCM

Explore this box plot interactively →