DCDC1

Across TCGA pan-cancer cohorts, DCDC1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated DCDC1 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DCDC1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated DCDC1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UCEC, LIHC, and LUSC are the cancer types where DCDC1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.296	<.001	36	view →
LIHC	OS	Median	III,IV	0.079	0.737	.004	12	view →
LUSC	DFS	Median	All	0.675	0.360	.004	12	view →
SKCM	OS	Median	III,IV	0.279	0.745	<.001	10	view →
SARC	DFS	Median	All	0.212	0.614	.016	6	view →
SCLC	OS	Median	All	0.082	0.653	.002	6	view →
KIRC	OS	Median	All	0.251	0.632	.016	5	view →
MESO	OS	Median	II,III,IV	0.180	0.560	.046	3	view →
LGG	DFS	Median	All	0.647	0.847	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

DCDC1–UCEC (DFS)

Open the UCEC breakdown →