DCDC1

Across TCGA patient cohorts, DCDC1 mutation is significantly associated with the RNA expression of many other genes, with 7,574 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCDC1-associated genes across cancer lineages are PBK, POC1A, and CENPA. Each is linked with DCDC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both DCDC1-to-partner and partner-to-DCDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PBK grouped by DCDC1-low versus DCDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCDC1→partner) and Y-score (partner→DCDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PBK →	+0.890	+1.885	<.001	<.001	3	6
STAD	POC1A →	+0.696	+3.389	<.001	.004	3	5
LUAD	CENPA →	+1.110	+2.777	<.001	<.001	3	5
UCEC	CCT7 →	+0.316	+1.664	<.001	<.001	3	5
UCEC	SAC3D1 →	+0.392	+1.584	<.001	<.001	3	5
UCEC	DIABLO →	+0.283	+2.021	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,574 associations by consensus.

PBK by DCDC1 expression — UCEC

Explore this box plot interactively →