DCDC1

Across TCGA cell cohorts, DCDC1 mutation is significantly associated with the RNA expression of many other genes, with 969 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DCDC1-associated genes across cancer lineages are HJURP, UBR3, and PRAMEF14. Each is linked with DCDC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DCDC1-to-partner and partner-to-DCDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HJURP grouped by DCDC1-low versus DCDC1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCDC1→partner) and Y-score (partner→DCDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HJURP →	+0.707	+3.070	<.001	.008	3	3
LARGE_INTESTINE	UBR3 →	+0.433	+1.628	.002	.007	3	3
STOMACH	PRAMEF14 →	+0.007	+2.662	.001	.007	3	3
OESOPHAGUS	CD300LB →	+0.005	+2.847	<.001	.004	3	2
BLOOD_Lymphoma	PROKR2 →	+0.035	+2.502	<.001	.003	3	2
OVARY	OR2M4 →	+0.086	+3.700	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 969 associations by consensus.

HJURP by DCDC1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →