DCDC1

Across TCGA cell cohorts, DCDC1 mutation is significantly associated with the mutation status of many other genes, with 4,081 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DCDC1-associated genes across cancer lineages are EVPL, TRPS1, and RYR1. Each is linked with DCDC1 in more than 6 cancer types. Because this analysis shows association rather than direction, both DCDC1-to-partner and partner-to-DCDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EVPL grouped by DCDC1-low versus DCDC1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCDC1→partner) and Y-score (partner→DCDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	EVPL →	+4.263	+4.263	.001	.001	1	7
LUNG_SCLC	TRPS1 →	+3.774	+1.951	.004	.004	1	7
LARGE_INTESTINE	RYR1 →	+1.087	+1.485	.008	.008	1	7
BLOOD_Lymphoma	DUOX1 →	+3.618	+2.647	.003	.003	1	7
LUNG_NSCLC_LUSC	MAP2 →	+3.263	+3.938	.002	.002	1	6
LUNG_NSCLC_LUAD	CDH23 →	+1.736	+2.345	<.001	<.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,081 associations by consensus.

EVPL by DCDC1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →