DCD

Across TCGA patient cohorts, DCD RNA expression is significantly associated with the go_rna of many other GO terms, with 6,596 significant associations in total. STAD shows the largest number of these associations.

The most reproducible DCD-associated GO terms across cancer lineages are rRNA modification, Negative regulation of Wnt signaling pathway, and Regulation of telomere maintenance in response to DNA damage. Each is linked with DCD in more than 8 cancer types. Because this analysis shows association rather than direction, both DCD-to-partner and partner-to-DCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA modification grouped by DCD-low versus DCD-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DCD→partner) and Y-score (partner→DCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	rRNA modification →	+0.053	+0.240	<.001	<.001	3	9
ESCA	Negative regulation of Wnt signaling pathway →	+0.049	+0.165	<.001	<.001	3	8
ESCA	Regulation of telomere maintenance in response to DNA damage →	+0.054	+0.156	<.001	<.001	3	8
STAD	ATP metabolic process →	+0.065	+0.252	<.001	<.001	3	8
STAD	Vesicle coating →	+0.055	+0.227	<.001	<.001	3	8
STAD	Exit from mitosis →	+0.060	+0.249	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,596 associations by consensus.

rRNA modification by DCD expression — STAD

Explore this box plot interactively →