DCD

Across TCGA patient cohorts, DCD mutation is significantly associated with the RNA expression of many other genes, with 63 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DCD-associated genes across cancer lineages are GIMAP1-GIMAP5, MTCYBP27, and NDUFB4P7. Each is linked with DCD in more than 1 cancer types. Because this analysis shows association rather than direction, both DCD-to-partner and partner-to-DCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GIMAP1-GIMAP5 grouped by DCD-low versus DCD-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCD→partner) and Y-score (partner→DCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	GIMAP1-GIMAP5 →	+0.021	+5.108	<.001	.008	3	1
LIHC	MTCYBP27 →	+0.121	+6.479	<.001	.001	3	1
COAD	NDUFB4P7 →	+0.109	+7.741	<.001	.009	3	1
COAD	XKRYP2 →	+0.084	+7.741	<.001	.009	3	1
COAD	RN7SKP190 →	+1.132	+7.741	<.001	.009	3	1
UCEC	SMARCE1P7 →	+0.183	+4.003	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

GIMAP1-GIMAP5 by DCD expression — LIHC

Explore this box plot interactively →