DCD

Across TCGA cell cohorts, DCD mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. CNS shows the largest number of these associations.

The most reproducible DCD-associated genes across cancer lineages are OR10G2, PGLYRP3, and OR1G1. Each is linked with DCD in more than 1 cancer types. Because this analysis shows association rather than direction, both DCD-to-partner and partner-to-DCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10G2 grouped by DCD-low versus DCD-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCD→partner) and Y-score (partner→DCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10G2 →	+0.074	+4.977	<.001	.007	3	1
CNS	PGLYRP3 →	+0.602	+5.754	<.001	.002	3	1
CNS	OR1G1 →	+0.029	+5.754	<.001	.002	3	1
CNS	S100A7A →	+0.106	+4.981	<.001	.008	3	1
CNS	KRTAP19-2 →	+0.128	+5.754	<.001	.002	3	1
CNS	KRT77 →	+0.061	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR10G2 by DCD expression — LARGE_INTESTINE

Explore this box plot interactively →