Across TCGA patient cohorts, DCC RNA expression is significantly associated with the protein abundance of many other proteins, with 12,193 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DCC-associated proteins across cancer lineages are MZB1, CD38, and CD79A. Each is linked with DCC in more than 5 cancer types. Because this analysis shows association rather than direction, both DCC-to-partner and partner-to-DCC results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DCC→partner) and Y-score (partner→DCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MZB1 →	+0.989	+0.472	<.001	.003	3	6
HNSC	CD38 →	+0.825	+0.576	<.001	<.001	3	6
HNSC	CD79A →	+1.029	+0.764	<.001	<.001	3	5
BRCA	CELF2 →	+0.466	+0.152	<.001	.006	3	5
LUAD	DERL3 →	+1.109	+0.691	<.001	<.001	3	5
BRCA	IKZF1 →	+0.447	+0.119	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,193 associations by consensus.

Exploration

DCC survival (RNA) · tumor vs normal (RNA) · all DCC data types