Across TCGA patient cohorts, DCC mutation is significantly associated with the RNA expression of many other genes, with 8,085 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCC-associated genes across cancer lineages are SDHB, DLGAP5, and TOMM40. Each is linked with DCC in more than 6 cancer types. Because this analysis shows association rather than direction, both DCC-to-partner and partner-to-DCC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCC→partner) and Y-score (partner→DCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SDHB →	+0.397	+1.736	<.001	<.001	3	6
LUAD	DLGAP5 →	+0.874	+2.248	.001	.005	3	6
STAD	TOMM40 →	+0.469	+2.218	.002	<.001	3	6
STAD	NARS1 →	+0.452	+2.601	<.001	<.001	3	6
UCEC	TXNL4A →	+0.334	+1.318	<.001	<.001	3	6
STAD	ACBD5 →	+0.564	+1.891	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,085 associations by consensus.

Exploration

DCC survival (RNA) · tumor vs normal (RNA) · all DCC data types