Across TCGA patient cohorts, DCC mutation is significantly associated with the total protein of many other genes, with 102 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCC-associated genes across cancer lineages are Caspase-7-cleavedD198, FoxM1, and Rictor_pT1135. Each is linked with DCC in more than 4 cancer types. Because this analysis shows association rather than direction, both DCC-to-partner and partner-to-DCC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCC→partner) and Y-score (partner→DCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.821	+2.132	.001	.008	3	5
STAD	FoxM1 →	+0.231	+1.938	.004	.007	3	4
STAD	Rictor_pT1135 →	-0.107	-1.684	.024	.038	3	4
COAD	ASNS →	+0.559	+2.882	<.001	<.001	3	4
UCEC	4E-BP1 →	+0.354	+1.898	<.001	<.001	3	4
UCEC	Cyclin-B1 →	+0.641	+1.584	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

Exploration

DCC survival (RNA) · tumor vs normal (RNA) · all DCC data types