Across TCGA cell cohorts, DCC RNA expression is significantly associated with the go_rna of many other GO terms, with 2,583 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DCC-associated GO terms across cancer lineages are tRNA transcription, Phospholipase C-activating G protein-coupled receptor signaling pathway, and RNA splicing, via transesterification reactions with bulged adenosine as nucleophile. Each is linked with DCC in more than 5 cancer types. Because this analysis shows association rather than direction, both DCC-to-partner and partner-to-DCC results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DCC→partner) and Y-score (partner→DCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	tRNA transcription →	+0.084	+1.339	.002	.001	3	5
STOMACH	Phospholipase C-activating G protein-coupled receptor signaling pathway →	-0.060	-0.098	<.001	.007	2	6
BONE	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.064	+2.148	.003	.003	3	5
BONE	mRNA splicing, via spliceosome →	+0.064	+2.148	.003	.003	3	5
BONE	Negative regulation of RNA catabolic process →	+0.054	+1.909	<.001	.001	3	5
BONE	RNA splicing, via transesterification reactions →	+0.062	+2.176	.004	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,583 associations by consensus.

Exploration

DCC survival (RNA) · tumor vs normal (RNA) · all DCC data types