Across TCGA cell cohorts, DCC mutation is significantly associated with the RNA expression of many other genes, with 679 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DCC-associated genes across cancer lineages are DNAJB8, CCDC144NL, and ASIC5. Each is linked with DCC in more than 1 cancer types. Because this analysis shows association rather than direction, both DCC-to-partner and partner-to-DCC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCC→partner) and Y-score (partner→DCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DNAJB8 →	+0.029	+3.142	<.001	.008	3	2
SOFT_TISSUE	CCDC144NL →	+1.665	+3.607	.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	ASIC5 →	+0.039	+3.722	.002	.007	3	2
PANCREAS	TRIM49B →	+0.018	+4.029	<.001	.007	3	2
PANCREAS	GAGE12J →	+0.038	+4.029	<.001	.007	3	2
URINARY_TRACT	OR2A4 →	+0.042	+3.584	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 679 associations by consensus.

Exploration

DCC survival (RNA) · tumor vs normal (RNA) · all DCC data types