DCBLD2

Across TCGA patient cohorts, DCBLD2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCBLD2-associated genes across cancer lineages are Annexin-1, EGFR_pY1068, and mTOR_pS2448. Each is linked with DCBLD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DCBLD2-to-partner and partner-to-DCBLD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by DCBLD2-low versus DCBLD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCBLD2→partner) and Y-score (partner→DCBLD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.453	+1.697	.005	.012	3	3
UCEC	EGFR_pY1068 →	-0.195	-1.415	.012	.010	3	2
UCEC	mTOR_pS2448 →	-0.096	-1.980	.037	.009	3	2
UCEC	VHL →	-0.711	-1.662	<.001	.010	3	2
UCEC	ATM →	-0.493	-2.893	<.001	.001	3	2
UCEC	C-Raf →	+0.163	+1.893	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Annexin-1 by DCBLD2 expression — UCEC

Explore this box plot interactively →