DCBLD1

Across TCGA patient cohorts, DCBLD1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCBLD1-associated genes across cancer lineages are eIF4E, mTOR_pS2448, and Annexin-1. Each is linked with DCBLD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCBLD1-to-partner and partner-to-DCBLD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by DCBLD1-low versus DCBLD1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCBLD1→partner) and Y-score (partner→DCBLD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.197	+2.347	.014	.019	3	2
UCEC	mTOR_pS2448 →	-0.128	-1.565	.011	.034	3	2
UCEC	Annexin-1 →	+0.664	+2.999	<.001	<.001	3	2
UCEC	ARID1A →	-0.155	-2.321	.016	.033	3	2
UCEC	ATM →	-0.429	-1.807	.005	.004	3	2
UCEC	EGFR_pY1068 →	-0.222	-2.807	.009	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

eIF4E by DCBLD1 expression — COAD

Explore this box plot interactively →