Across TCGA pan-cancer cohorts, DCAF8L1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DCAF8L1 data layer compared with 15 for mass-spec protein.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DCAF8L1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated DCAF8L1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.
UCEC, CESC, and PRAD are the cancer types where DCAF8L1 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.