DCAF8

Across TCGA pan-cancer cohorts, DCAF8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DCAF8 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DCAF8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DCAF8 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where DCAF8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.848	0.304	<.001	36	view →
PDAC	DFS	Quartile	All	0.585	0.260	.004	23	view →
LSCC	OS	Median	III,IV	0.509	0.923	.005	16	view →
LUAD	DFS	Median	II,III,IV	0.736	0.903	.009	11	view →
UCEC	DFS	Median	All	0.970	0.844	.007	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DCAF8–CCRCC (DFS)

Open the CCRCC breakdown →