DCAF8

Across TCGA patient cohorts, DCAF8 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCAF8-associated genes across cancer lineages are eIF4E, eEF2, and p38-MAPK_pT180_Y182. Each is linked with DCAF8 in more than 2 cancer types. Because this analysis shows association rather than direction, both DCAF8-to-partner and partner-to-DCAF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by DCAF8-low versus DCAF8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCAF8→partner) and Y-score (partner→DCAF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.208	+2.906	.006	.001	3	3
UCEC	eEF2 →	+0.275	+2.321	.032	.033	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.350	-2.584	.030	.010	3	2
UCEC	Shc_pY317 →	-0.220	-3.169	<.001	<.001	3	2
UCEC	C-Raf →	+0.177	+3.459	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.103	-3.558	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

eIF4E by DCAF8 expression — UCEC

Explore this box plot interactively →