DCAF8

Across TCGA cell cohorts, DCAF8 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DCAF8-associated genes across cancer lineages are SNTG1, CALN1, and RALYL. Each is linked with DCAF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCAF8-to-partner and partner-to-DCAF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNTG1 grouped by DCAF8-low versus DCAF8-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCAF8→partner) and Y-score (partner→DCAF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SNTG1 →	+0.041	+3.584	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	CALN1 →	+0.062	+3.917	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	RALYL →	+0.029	+3.954	<.001	.009	3	1
LUNG_NSCLC_LUAD	BHLHE23 →	+0.068	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR10AG1 →	+0.032	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	EDDM3B →	+0.059	+4.734	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

SNTG1 by DCAF8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →