DCAF4L1

Across TCGA pan-cancer cohorts, DCAF4L1 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated DCAF4L1 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher DCAF4L1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DCAF4L1 expression acts as an unfavorable survival marker, although some lineages such as ESCA show a favorable association.

KICH, BRCA, and LIHC are the cancer types where DCAF4L1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.081	0.904	<.001	30	view →
BRCA	OS	Median	All	0.572	0.963	<.001	24	view →
LIHC	OS	Median	II,III,IV	0.010	0.716	<.001	12	view →
ESCA	DFS	Median	III,IV	1.000	0.382	.025	7	view →
SARC	DFS	Median	All	0.109	0.611	.030	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUAD	DFS	Median	All	0.208	0.678	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	OS	Median	III,IV	0.245	0.721	.018	4	view →
COAD	OS	Median	III,IV	0.168	0.692	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

DCAF4L1–KICH (DFS)

Open the KICH breakdown →