DCAF4L1

Across TCGA patient cohorts, DCAF4L1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCAF4L1-associated genes across cancer lineages are p62 Lck ligand, P-Cadherin, and Rad50. Each is linked with DCAF4L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCAF4L1-to-partner and partner-to-DCAF4L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by DCAF4L1-low versus DCAF4L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCAF4L1→partner) and Y-score (partner→DCAF4L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.200	+1.222	.030	.011	3	2
UCEC	P-Cadherin →	-0.084	-1.807	.039	.024	3	2
COAD	Rad50 →	-0.341	-2.321	<.001	.032	3	2
UCEC	Annexin-1 →	+0.558	+2.736	<.001	<.001	3	2
COAD	LKB1 →	+0.072	+3.321	.047	.009	3	2
UCEC	14-3-3_beta →	-0.082	-1.385	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

p62 Lck ligand by DCAF4L1 expression — UCEC

Explore this box plot interactively →