DCAF4L1

Across TCGA cell cohorts, DCAF4L1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,013 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DCAF4L1-associated GO terms across cancer lineages are Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, Nuclear-transcribed mRNA catabolic process, and Spliceosomal complex assembly. Each is linked with DCAF4L1 in more than 13 cancer types. Because this analysis shows association rather than direction, both DCAF4L1-to-partner and partner-to-DCAF4L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by DCAF4L1-low versus DCAF4L1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DCAF4L1→partner) and Y-score (partner→DCAF4L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.177	+0.321	<.001	<.001	3	14
LARGE_INTESTINE	Nuclear-transcribed mRNA catabolic process →	+0.058	+0.258	<.001	.001	3	13
BONE	Spliceosomal complex assembly →	+0.105	+0.276	<.001	<.001	3	13
BONE	Positive regulation of telomerase RNA localization to Cajal body →	+0.103	+0.237	<.001	.002	2	13
PANCREAS	Regulation of RNA splicing →	+0.063	+0.301	.001	.001	3	12
PANCREAS	Regulation of telomerase RNA localization to Cajal body →	+0.109	+0.373	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,013 associations by consensus.

Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I by DCAF4L1 expression — BONE

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