DCAF4

Across TCGA pan-cancer cohorts, DCAF4 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated DCAF4 data layer compared with 3 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher DCAF4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DCAF4 expression acts as an unfavorable survival marker, although some lineages such as READ and KIRC show a favorable association.

ACC, LIHC, and READ are the cancer types where DCAF4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.243	0.634	<.001	44	view →
LIHC	OS	Tertile	All	0.582	0.778	<.001	42	view →
READ	OS	Median	All	0.941	0.684	.002	32	view →
UCS	OS	Median	III,IV	0.244	0.630	.009	28	view →
UCEC	DFS	Median	All	0.793	0.879	.001	24	view →
LUSC	DFS	Quartile	III,IV	0.206	0.935	.001	23	view →
KIRC	DFS	Quartile	All	0.785	0.485	.005	19	view →
PAAD	OS	Median	II,III,IV	0.446	0.650	.008	18	view →
SARC	OS	Tertile	All	0.760	0.961	<.001	13	view →
CHOL	DFS	Median	II,III,IV	0.633	0.128	.030	9	view →
LGG	OS	Quartile	All	0.770	0.887	.007	6	view →
GBM	OS	Tertile	All	0.356	0.535	.010	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

DCAF4–ACC (DFS)

Open the ACC breakdown →