DCAF4

Across TCGA pan-cancer cohorts, DCAF4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DCAF4 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DCAF4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DCAF4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and BLCA are the cancer types where DCAF4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.355	0.753	<.001	64	view →
UCEC	DFS	Median	II,III,IV	1.000	0.437	.014	26	view →
BLCA	OS	Median	IV	0.183	0.598	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DCAF4–HNSC (OS)

Open the HNSC breakdown →