DCAF17

Across TCGA patient cohorts, DCAF17 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCAF17-associated genes across cancer lineages are mTOR_pS2448, Shc_pY317, and MEK1. Each is linked with DCAF17 in more than 2 cancer types. Because this analysis shows association rather than direction, both DCAF17-to-partner and partner-to-DCAF17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by DCAF17-low versus DCAF17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCAF17→partner) and Y-score (partner→DCAF17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.150	-2.986	.031	.035	3	3
UCEC	Shc_pY317 →	-0.179	-2.584	.011	.011	3	2
UCEC	MEK1 →	+0.418	+3.700	.014	.001	3	1
UCEC	MSH2 →	-0.327	-3.143	.002	.018	3	1
UCEC	PI3K-p110-a →	-0.170	-3.169	.038	.019	3	1
UCEC	Annexin-1 →	+0.488	+3.019	.047	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

mTOR_pS2448 by DCAF17 expression — UCEC

Explore this box plot interactively →