DCAF17

Across TCGA cell cohorts, DCAF17 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DCAF17-associated genes across cancer lineages are USP17L20, CDH20, and DEFA4. Each is linked with DCAF17 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCAF17-to-partner and partner-to-DCAF17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L20 grouped by DCAF17-low versus DCAF17-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCAF17→partner) and Y-score (partner→DCAF17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	USP17L20 →	+0.007	+5.169	<.001	<.001	3	2
LARGE_INTESTINE	CDH20 →	+0.127	+3.766	<.001	.004	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	FAM187B →	+0.020	+3.347	.003	.005	3	1
LARGE_INTESTINE	BPIFA1 →	+0.149	+5.009	<.001	<.001	3	1
UPPER_AERODIGESTIVE_TRACT	MMD2 →	+0.036	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

USP17L20 by DCAF17 expression — LUNG_SCLC

Explore this box plot interactively →