DCAF16

Across TCGA patient cohorts, DCAF16 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCAF16-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and INPP4B. Each is linked with DCAF16 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCAF16-to-partner and partner-to-DCAF16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by DCAF16-low versus DCAF16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCAF16→partner) and Y-score (partner→DCAF16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.200	-2.321	.034	.033	3	1
UCEC	A-Raf_pS299 →	-0.111	-1.765	.013	.014	3	1
UCEC	INPP4B →	-0.298	-3.459	.013	.005	3	1
UCEC	MEK1 →	+0.482	+3.807	<.001	<.001	3	1
UCEC	Notch1 →	+0.133	+1.817	.012	.015	3	1
UCEC	PKC-a →	+0.327	+1.750	.031	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

EGFR_pY1068 by DCAF16 expression — UCEC

Explore this box plot interactively →