DCAF15

Across TCGA patient cohorts, DCAF15 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCAF15-associated genes across cancer lineages are Notch1, EGFR, and 14-3-3_beta. Each is linked with DCAF15 in more than 2 cancer types. Because this analysis shows association rather than direction, both DCAF15-to-partner and partner-to-DCAF15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by DCAF15-low versus DCAF15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCAF15→partner) and Y-score (partner→DCAF15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.113	+1.887	.040	.029	3	3
UCEC	EGFR →	-0.139	-2.000	.027	.010	3	2
UCEC	14-3-3_beta →	-0.108	-1.571	.006	.036	3	1
UCEC	eIF4E →	+0.167	+2.183	.043	.033	3	1
UCEC	A-Raf_pS299 →	-0.187	-2.700	<.001	.006	3	1
UCEC	Fibronectin →	-0.338	-2.502	.009	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Notch1 by DCAF15 expression — UCEC

Explore this box plot interactively →