DCAF13

Across TCGA cell cohorts, DCAF13 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible DCAF13-associated genes across cancer lineages are C20orf173, TRIM64B, and HIGD1C. Each is linked with DCAF13 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCAF13-to-partner and partner-to-DCAF13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf173 grouped by DCAF13-low versus DCAF13-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCAF13→partner) and Y-score (partner→DCAF13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	C20orf173 →	+0.177	+3.758	<.001	.007	3	1
BREAST	TRIM64B →	+0.119	+3.672	<.001	.006	3	1
BREAST	HIGD1C →	+0.093	+3.672	.008	.006	3	1
BREAST	MBD3L2 →	+0.631	+3.672	<.001	.006	3	1
BREAST	DUXA →	+0.059	+4.064	.008	.003	3	1
BLOOD_Lymphoma	CCL21 →	+0.322	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

C20orf173 by DCAF13 expression — BREAST

Explore this box plot interactively →