Across TCGA patient cohorts, DCAF12 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCAF12-associated genes across cancer lineages are XBP1, ER-alpha_pS118, and HER3_pY1289. Each is linked with DCAF12 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCAF12-to-partner and partner-to-DCAF12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCAF12→partner) and Y-score (partner→DCAF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	XBP1 →	-0.213	-3.000	.040	.036	3	2
BLCA	ER-alpha_pS118 →	+0.208	+2.820	<.001	.035	3	1
BLCA	HER3_pY1289 →	+0.126	+2.999	.042	.035	3	1
BLCA	PEA-15 →	-0.252	-2.982	.023	.036	3	1
UCEC	14-3-3_beta →	-0.101	-2.295	.012	.033	3	1
UCEC	eIF4E →	+0.167	+1.906	.048	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

DCAF12 survival (RNA) · tumor vs normal (RNA) · all DCAF12 data types