DCAF11

Across TCGA pan-cancer cohorts, DCAF11 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated DCAF11 data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DCAF11 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated DCAF11 expression acts as an unfavorable survival marker, although some lineages such as KIRC and MESO show a favorable association.

KIRC, MESO, and UVM are the cancer types where DCAF11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.724	0.534	<.001	103	view →
MESO	OS	Median	All	0.683	0.405	<.001	93	view →
UVM	DFS	Quartile	III,IV	0.920	0.295	<.001	72	view →
KIRP	DFS	Quartile	II,III,IV	0.808	0.248	.003	61	view →
UCS	DFS	Median	IV	0.909	0.416	.008	30	view →
LGG	DFS	Tertile	All	0.880	0.777	.001	27	view →
ACC	DFS	Median	All	0.246	0.653	<.001	23	view →
COAD	DFS	Median	IV	0.349	0.598	.003	18	view →
HNSC	OS	Quartile	All	0.214	0.601	.004	15	view →
BRCA	DFS	Tertile	III,IV	0.931	0.807	.017	12	view →
ESCA	OS	Median	IV	0.222	0.698	.006	12	view →
LUSC	DFS	Tertile	III,IV	0.512	0.722	.008	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

DCAF11–KIRC (DFS)

Open the KIRC breakdown →