DCAF11

Across TCGA pan-cancer cohorts, DCAF11 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated DCAF11 data layer compared with 20 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DCAF11 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DCAF11 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

HNSC, BLCA, and COAD are the cancer types where DCAF11 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.021	0.712	<.001	30	view →
BLCA	OS	Median	All	0.192	0.620	.006	30	view →
COAD	OS	Median	II,III,IV	0.159	0.785	.015	12	view →
UCEC	DFS	Median	III,IV	1.000	0.541	.037	10	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	9	view →
UVM	DFS	Median	All	0.180	0.744	.019	6	view →
SARC	OS	Median	All	0.175	0.745	.007	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
STAD	OS	Median	III,IV	1.000	0.365	.030	6	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

DCAF11–HNSC (OS)

Open the HNSC breakdown →