DCAF1

Across TCGA patient cohorts, DCAF1 mutation is significantly associated with the RNA expression of many other genes, with 3,473 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCAF1-associated genes across cancer lineages are HDGFL2, RNU6-960P, and RNU6-1305P. Each is linked with DCAF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DCAF1-to-partner and partner-to-DCAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HDGFL2 grouped by DCAF1-low versus DCAF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCAF1→partner) and Y-score (partner→DCAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HDGFL2 →	+0.412	+2.269	<.001	<.001	3	3
CESC	RNU6-960P →	+0.112	+4.247	<.001	.007	3	3
HNSC	RNU6-1305P →	+0.218	+4.327	<.001	.009	3	3
UCEC	PACSIN2 →	+0.474	+2.021	<.001	.001	3	3
UCEC	PSMB7 →	+0.351	+1.638	<.001	<.001	3	3
CESC	MIR8053 →	+0.244	+4.020	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,473 associations by consensus.

HDGFL2 by DCAF1 expression — UCEC

Explore this box plot interactively →