DCAF1

Across TCGA cell cohorts, DCAF1 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DCAF1-associated genes across cancer lineages are CCL18, CST4, and BMP15. Each is linked with DCAF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCAF1-to-partner and partner-to-DCAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL18 grouped by DCAF1-low versus DCAF1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCAF1→partner) and Y-score (partner→DCAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CCL18 →	+0.037	+4.628	<.001	.001	3	2
BLOOD_Lymphoma	CST4 →	+0.383	+3.736	.006	.009	3	1
BLOOD_Lymphoma	BMP15 →	+0.017	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	MROH2B →	+0.069	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	KRTAP3-3 →	+0.036	+4.662	<.001	.003	3	1
BLOOD_Lymphoma	OR4A47 →	+0.013	+4.058	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

CCL18 by DCAF1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →