DBX1

Across TCGA pan-cancer cohorts, DBX1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DBX1 data layer compared with 19 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher DBX1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DBX1 expression acts as an unfavorable survival marker, although some lineages such as LUSC show a favorable association.

ESCA, UCEC, and LUSC are the cancer types where DBX1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	II,III,IV	0.159	0.525	.008	24	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUSC	DFS	Median	All	1.000	0.370	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DBX1–ESCA (DFS)

Open the ESCA breakdown →