DBT

Across TCGA patient cohorts, DBT mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DBT-associated genes across cancer lineages are NF2, S6_pS240_S244, and 14-3-3_beta. Each is linked with DBT in more than 1 cancer types. Because this analysis shows association rather than direction, both DBT-to-partner and partner-to-DBT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by DBT-low versus DBT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBT→partner) and Y-score (partner→DBT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF2 →	+0.258	+2.321	.003	.034	3	2
UCEC	S6_pS240_S244 →	+0.537	+2.335	.001	.018	3	2
UCEC	14-3-3_beta →	-0.125	-3.295	.002	.009	3	1
UCEC	eEF2 →	+0.304	+2.999	.039	.035	3	1
UCEC	EGFR_pY1068 →	-0.329	-3.459	.001	.005	3	1
UCEC	A-Raf_pS299 →	-0.168	-2.584	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

NF2 by DBT expression — UCEC

Explore this box plot interactively →