DBT

Across TCGA cell cohorts, DBT mutation is significantly associated with the mutation status of many other genes, with 3,061 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DBT-associated genes across cancer lineages are ABCA10, NEGR1, and TP53BP1. Each is linked with DBT in more than 3 cancer types. Because this analysis shows association rather than direction, both DBT-to-partner and partner-to-DBT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABCA10 grouped by DBT-low versus DBT-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBT→partner) and Y-score (partner→DBT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ABCA10 →	+2.857	+4.142	.008	.008	1	4
SKIN	NEGR1 →	+5.824	+5.824	.002	.002	1	4
LARGE_INTESTINE	TP53BP1 →	+2.070	+2.807	.002	.002	1	3
BREAST	NLRC5 →	+3.857	+4.807	.002	.002	1	3
BREAST	SPAG16 →	+4.857	+4.297	.009	.009	1	3
BREAST	GAB3 →	+4.857	+4.297	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,061 associations by consensus.

ABCA10 by DBT expression — BREAST

Explore this box plot interactively →