DBR1

Across TCGA pan-cancer cohorts, DBR1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of DBR1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DBR1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types DBR1 is over-expressed in tumor.

COAD, HNSC, and LSCC are the cancer types where DBR1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DBR1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.252	<.001	9	view →
HNSC	Male	IV	+0.367	<.001	8	view →
LSCC	Male	All	+0.357	<.001	8	view →
LUAD	Male	All	+0.128	<.001	4	view →
CCRCC	All	All	+0.052	.019	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

DBR1–COAD

Open the COAD breakdown →