DBR1

Across TCGA patient cohorts, DBR1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DBR1-associated genes across cancer lineages are eEF2, ERK2, and JNK2. Each is linked with DBR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DBR1-to-partner and partner-to-DBR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by DBR1-low versus DBR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBR1→partner) and Y-score (partner→DBR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.287	+1.584	.040	.036	3	1
UCEC	ERK2 →	+0.159	+1.874	.036	.049	3	1
UCEC	JNK2 →	+0.196	+2.834	.011	.034	3	1
UCEC	MEK1 →	+0.283	+2.000	.049	.010	3	1
UCEC	MSH6 →	-0.315	-1.584	.015	.036	3	1
UCEC	PDK1_pS241 →	+0.184	+3.700	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

eEF2 by DBR1 expression — UCEC

Explore this box plot interactively →