DBR1

Across TCGA cell cohorts, DBR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,300 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DBR1-associated GO terms across cancer lineages are DNA integrity checkpoint signaling, Cell cycle checkpoint signaling, and DNA damage checkpoint signaling. Each is linked with DBR1 in more than 17 cancer types. Because this analysis shows association rather than direction, both DBR1-to-partner and partner-to-DBR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA integrity checkpoint signaling grouped by DBR1-low versus DBR1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DBR1→partner) and Y-score (partner→DBR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DNA integrity checkpoint signaling →	+0.100	+1.115	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Cell cycle checkpoint signaling →	+0.089	+1.093	<.001	<.001	3	18
PANCREAS	DNA damage checkpoint signaling →	+0.086	+1.015	<.001	<.001	3	17
PANCREAS	DNA recombination →	+0.087	+0.726	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle process →	+0.076	+0.922	<.001	<.001	3	16
OESOPHAGUS	Replication fork processing →	+0.132	+0.612	.004	.006	2	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,300 associations by consensus.

DNA integrity checkpoint signaling by DBR1 expression — PANCREAS

Explore this box plot interactively →