DBP

Across TCGA pan-cancer cohorts, DBP mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DBP data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher DBP mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DBP expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

GBM, HNSC, and LUAD are the cancer types where DBP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	1.000	0.813	.019	13	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.928	.025	12	view →
LUAD	DFS	Tertile	All	0.896	1.000	.009	7	view →
UCEC	DFS	Median	All	0.773	1.000	.033	4	view →
PDAC	OS	Quartile	All	0.792	0.354	.017	4	view →
CCRCC	DFS	Median	II,III,IV	0.692	1.000	.045	3	view →
LSCC	DFS	Median	All	0.960	0.884	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DBP–GBM (OS)

Open the GBM breakdown →