DBP

Across TCGA patient cohorts, DBP mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DBP-associated genes across cancer lineages are ATM, FoxM1, and Ku80. Each is linked with DBP in more than 1 cancer types. Because this analysis shows association rather than direction, both DBP-to-partner and partner-to-DBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DBP-low versus DBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBP→partner) and Y-score (partner→DBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.442	-2.584	.036	.011	3	2
UCEC	FoxM1 →	+0.273	+2.817	.023	.036	3	1
UCEC	Ku80 →	+0.235	+2.598	.032	.006	3	1
UCEC	p62 Lck ligand →	+0.344	+2.584	.023	.011	3	1
UCEC	PKC-delta_pS664 →	-0.135	-3.160	.015	.019	3	1
UCEC	Annexin-1 →	+0.696	+2.189	.004	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ATM by DBP expression — UCEC

Explore this box plot interactively →