DBNDD2

Across TCGA patient cohorts, DBNDD2 mutation is significantly associated with the RNA expression of many other genes, with 2,391 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DBNDD2-associated genes across cancer lineages are BTBD10, LIN7C, and HSD17B12. Each is linked with DBNDD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DBNDD2-to-partner and partner-to-DBNDD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BTBD10 grouped by DBNDD2-low versus DBNDD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBNDD2→partner) and Y-score (partner→DBNDD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BTBD10 →	+0.534	+3.839	<.001	<.001	3	1
UCEC	LIN7C →	+0.537	+2.743	.003	.002	3	1
UCEC	HSD17B12 →	+0.516	+2.606	.003	.005	3	1
UCEC	PTPRJ →	+0.945	+2.595	<.001	<.001	3	1
UCEC	COX15 →	+0.419	+4.008	.002	<.001	3	1
UCEC	INTS4 →	+0.369	+2.617	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,391 associations by consensus.

BTBD10 by DBNDD2 expression — UCEC

Explore this box plot interactively →