DBN1

Across TCGA patient cohorts, DBN1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DBN1-associated genes across cancer lineages are RAD51, ATM, and Collagen-VI. Each is linked with DBN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DBN1-to-partner and partner-to-DBN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by DBN1-low versus DBN1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBN1→partner) and Y-score (partner→DBN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RAD51 →	+0.185	+3.178	.017	.010	3	2
UCEC	ATM →	-0.568	-3.156	<.001	<.001	3	2
UCEC	Collagen-VI →	-0.182	-2.986	.003	<.001	3	2
UCEC	C-Raf →	+0.152	+1.392	<.001	.017	3	2
COAD	TIGAR →	+0.581	+3.178	.002	.010	1	3
UCEC	14-3-3_beta →	-0.081	-1.738	.008	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

RAD51 by DBN1 expression — COAD

Explore this box plot interactively →